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crizotinib increases levels of modafinil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Keep an eye on. Dose reduction can be required for coadministered medication that are predominantly metabolized by CYP3A.Watch Intently (one)modafinil will raise the degree or effect of flibanserin by impacting hepatic enzyme CYP2C19 metab